ObjectiveRegular exercise is a powerful tool that enhances skeletal muscle mass and strength.Lysine acetylation is an important post-translational modification (PTM) involved in a broad array of cellular functions.Skeletal muscle protein contains a considerable number of lysine-acetylated (Kac) sites, so we aimed to investigate the effects of exerc
Purpose: To describe a case of primary lacrimal sac adenocarcinoma treated primarily with androgen deprivation therapy (ADT) with good clinic response.Observations: An 82-year-old male presented with a painless right orbital mass.Pathology following partial resection was consistent with primary lacrimal sac adenocarcinoma positive for androgen rece
Abstract Cancer is a leading cause of death worldwide.Targeted therapies aimed at key oncogenic driver mutations in combination with chemotherapy and radiotherapy as well as immunotherapy have benefited cancer patients considerably.Tumor protein p53 (TP53), a crucial tumor suppressor gene encoding p53, regulates numerous downstream genes and cellul
Introduction: Peripheral arterial disease (PAD) impedes the ability to recover from lower extremity arthroplasties (LEA) while simultaneously increasing risks of peri- and postoperative complications, morbidity, and mortality.Despite Toggle Switch the known risks that PAD presents, there are currently no standards outlining how practitioners should